The Impact of Gut Microbiome on Prostate Health and BPH Progression: A Comprehensive Review

 Mugisha Emmanuel K.

Faculty of Science and Technology Kampala International University Uganda

ABSTRACT

Benign Prostatic Hyperplasia (BPH) is a prevalent condition in aging men, characterized by prostate enlargement and associated lower urinary tract symptoms (LUTS). While traditional risk factors include age, hormonal imbalances, and genetics, recent research suggests that the gut microbiome may significantly influence prostate health and BPH progression. The gut microbiome, comprising trillions of microorganisms, plays a crucial role in systemic processes such as inflammation, immune modulation, and hormonal regulation, all of which are implicated in BPH pathogenesis. This comprehensive review explores the mechanisms linking gut dysbiosis to prostate health, with a focus on systemic inflammation, hormonal disturbances, and immune responses. Dysbiosis, or an imbalance in gut microbial communities, can lead to chronic inflammation, elevated levels of pro-inflammatory cytokines, and disruptions in androgen and estrogen metabolism, contributing to the onset and progression of BPH. Emerging evidence from both animal and human studies highlights significant differences in the gut microbiota of men with BPH compared to healthy controls, suggesting a potential role for microbiome-based interventions. Furthermore, the review discusses the therapeutic potential of probiotics, prebiotics, and dietary modifications in modulating gut health to alleviate BPH symptoms. Personalized microbiome-targeted therapies represent a promising avenue for future research. This review underscores the importance of the gut-prostate axis in understanding prostate health and suggests that targeting the gut microbiome could lead to novel strategies for preventing and managing BPH.

Keywords: Gut microbiome, Prostate health, Benign Prostatic Hyperplasia, Urinary tract symptoms, Dysbiosis

CITE AS: Mugisha Emmanuel K. (2024). The Impact of Gut Microbiome on Prostate Health and BPH Progression: A Comprehensive Review. IDOSR JOURNAL OF SCIENTIFIC RESEARCH 9(3)1-7. https://doi.org/10.59298/IDOSRJSR/2024/9.3.17.100