Evaluation of Musa acuminata Starch as a Diluent in Paracetamol Tablet Formulations

Tansah Mbunwe

School of Pharmacy Kampala International University, Uganda

ABSTRACT

Tablet formulation, a widely used dosage form, relies on excipients like diluents to ensure product quality. This study investigates the potential of Musa acuminata (matoke banana) starch as a diluent in paracetamol tablets. Starch was extracted from matoke bananas and formulated into three batches using wet granulation, with concentrations of 5%, 10%, and 15% w/w. Comparative analysis was conducted with maize starch. Physiochemical properties of starch and granules, as well as tablet characteristics, were evaluated. Results indicated comparable properties between matoke and maize starches. Tablets formulated with matoke starch exhibited optimal disintegration time, hardness, friability, and weight uniformity, suggesting its potential as a cost-effective and accessible alternative diluent.

Keywords: Matoke, Musa acuminate, Starch, Active pharmaceutical and ingredients

CITE AS: Tansah Mbunwe (2024). Evaluation of Musa acuminata Starch as a Diluent in Paracetamol Tablet Formulations. IDOSR JOURNAL OF BIOCHEMISTRY, BIOTECHNOLOGY AND ALLIED FIELDS 9(2):54-59. https://doi.org/10.59298/IDOSR/JBBAF/24/92.545910000