Impact of Intermittent Fasting on Lipid Profiles in Obese Individuals with Metabolic Complications: A Mini-Review

Odile Patrick Thalia

Faculty of Biological Sciences Kampala International University Uganda

ABSTRACT

Intermittent fasting (IF) has emerged as a popular dietary approach with potential health benefits, particularly in managing obesity and its associated metabolic complications. This review explores the impact of IF on lipid profiles in obese individuals with metabolic disorders such as type 2 diabetes, dyslipidemia, and insulin resistance. IF regimens, including alternate-day fasting, the 5:2 diet, and time-restricted feeding, have shown promising results in modulating lipid metabolism, reducing total cholesterol, triglycerides, and low-density lipoprotein (LDL) levels while increasing high-density lipoprotein (HDL) levels. The mechanisms underlying these changes involve shifts in energy metabolism, increased fatty acid oxidation, improved insulin sensitivity, and reduced inflammation. Additionally, the review highlights the role of IF in weight loss, body composition improvement, and reduction of cardiovascular risk factors. However, there is variability in the magnitude of lipid profile improvements depending on factors such as the specific IF regimen, duration, and individual metabolic status. Further long-term studies are required to elucidate the sustainability and clinical relevance of these changes in lipid profiles. This review provides insights into the potential of IF as a therapeutic strategy for lipid management in obese individuals with metabolic complications.

Keywords: Intermittent fasting, lipid profiles, obesity, metabolic complications, dyslipidemia, insulin resistance

CITE AS: Odile Patrick Thalia (2024). Impact of Intermittent Fasting on Lipid Profiles in Obese Individuals with Metabolic Complications: A Mini-Review. IDOSR JOURNAL OF BIOLOGY, CHEMISTRY AND PHARMACY 9(2):1-3. https://doi.org/10.59298/IDOSR/JBCP/24/92.1300