Synthesis, Physicochemical and Antimicrobial Studies of Schiff base derived from 2, 4-dinitrophenyl hydrazine with Salicyldehyde and its Co (II) and Ni (II) Complexes

Mukhtar Haruna¹, J.A. Ndahi¹, B. F. Dowell¹ and F.T. Sadauki²

 ¹Department of Chemistry, Modibbo Adama University (MAU), Yola.

  ²Department of Science Laboratory Technology, F.C.H. Dakin Kowa, Gombe.

 Corresponding author: mukhtar.haruna@mau.edu.ng; +2348034262702

ABSTRACT

A Schiff base ligand derived from salicylaldehyde and 2, 4-dinitrophenylhydrazine was synthesized, along with its Co(II) and Ni(II) complexes (CoL2 and NiL2). These compounds were characterized by melting point/decomposition temperature, solubility, molar conductance, magnetic susceptibility, infrared analysis, and UV-visible spectrophotometry. The metal-ligand ratio in the complexes is 1:2. All complexes exhibited low molar conductance values (5.2-11.0), indicating their non-electrolytic nature. The synthesized ligand and its metal (II) complexes were evaluated for antibacterial activity against five bacterial isolates (Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus) and three fungal isolates (Fusarium solani, Aspergillus fumigatus, and Candida albicans) using the well diffusion method. The results demonstrated that the metal complexes exhibited greater antimicrobial activity compared to the Schiff base ligand.

Keywords: Isolates, Conductance value, Synthesis, Non-electrolytic, Fusarium solani

CITE AS: Mukhtar Haruna, J.A. Ndahi, B. F Dowell and F.T. Sadauki (2024). Synthesis, Physicochemical and Antimicrobial Studies of Schiff base derived from 2, 4-dinitrophenyl hydrazine with Salicyldehyde and its Co (II) and Ni (II) Complexes. IDOSR JOURNAL OF SCIENTIFIC RESEARCH 9(2)1-12. https://doi.org/10.59298/IDOSRJSR/2024/9.2.1211.100